Native - Hyperion hands down.
I have two in my fleet, but only deploy one at a time, and always take control of it. I kitted it with a couple heavy blasters for massive alpha damage that quickly overloads most shields. It's got extended and stabilized shields with 20 capacitors, 10 flux vents, and resistant flux vents to soak up damage, and vent the flux faster. I'ts also got two tactical lasers, and an integrated targeting unit. The tactical lasers are more powerful than PD lasers, and I think longer range than LR PD lasers, so they help dish out the pain, but the ITU takes care of those pesky missiles that barely do damage to the shields (and are easy to avoid in the hyperion).
I support it with a couple Auroras, and an Apogee, they're mostly meat shields to keep the enemy fleet distracted while I pick it apart. I've also added a few Tempest frigates with unstable injectors and augmented engines to chase down running fighters and hounds (the Hyperion can chase them all down with a player at the helm, but the Tempest works better for the native AI). Together this fleet is enough to dominate the sector in native, no matter what I find.
PS. The most awesome part of the Hyperion is that it's completely energy based - I've been in some pretty long fights, and came out on top even when modules started failing due to long deployment because I used the shields to soak everything up, and vented when safe, then back into the fray.