Yeah the lore doesn't really need to explicitly justify EVERY gameplay mechanic does it?
Why not, I think it's fun to try. The fewer logic gaps there are, the easier it is to immerse in the game world, at least for me. As long as the gameplay is not altered just to be more explainable, but that's nothing I can see Alex do, ever.
Something I miss about games from my childhood is how I used to be able to fill in the gaps with my imagination. Part of it is that, since I'm no longer a child, my imagination isn't as rampant, but also modern games feel the need to explain everything. I'm perfectly happy with a game not providing an explanation for every little thing since it leaves room for me to interject my own thoughts and theories.
That being said, I also really like story in my games. I'm okay with a game explaining things if it adds to that. I should really think up some question about the lore, since it's started to pique my interest.
EDIT: Ok, here are a couple-
• How is power derived from Infernium? Is it just a good source of nuclear energy or does it generate power through more exotic means?
• If it generates power through more exotic means, what makes certain isotopes of Infernium useful as energy and what ends up as depleted Infernium?
• Why use depleted Infernium as ammo in certain guns (like the Gauss cannon) rather than something plentiful and dense like lead?