For PD heavy burst laser all day every day, for what you want which seems to be strike ability, pulse laser but if you really want them to be effective you'll splurge for those heavy blasters they seem ineffective but that much flux coming at a target at once is usually enough to make them back down or seriously think about venting in the middle of a fight. the true difference in the heavy blasters versus pulse lasers isn't DPS, its the amount of time, while your dealing that damage that your enemy has to shoot back at you. With a pulse laser they have a lot of it, because it takes the pulse laser quite a bit of time to equal the one shot damage of a heavy blaster pair that with the flux generated per shot from your own guns and the enemy shooting your shields and your better off with the blasters.
A weapon outfit for the Medusa i like for when i use it is to cover the thing in PD beams like burst pd except the small universals, and the medium energy, stick 4 AM blasters in there and that Medusa ( assuming you pilot it ) will obliterate just about anything that comes up to it, and in a fleet with someone bigger and slower to play distraction it makes an excellent striker for getting behind your target and wiping them off the face of the universe.
A similar loadout if your really good at piloting and have some tech skills or combat skills increasing your armor and speed for free is to put Am blasters all over the thing, in EVERY slot, at first this seems like automatic suicide due to lack of PD, and it would be if you let the ai have it but i've used one of these to great effect, it can one or two shot just about anything below capital ship, and seriously cripple capitals in one pass, the exception is Paragons, unless you again have something big enough to distract it's guns from you.
The thing about having that many AM blasters is to not care about not hitting shields, with that many you'll either add enough flux to a ship that it can't fire and has to drop shields to vent, or just straight up overloads, again the exception is Paragons and their fortress shield, and Onslaughts, if you're hitting an Onslaught's shields that means your infront of it, and that is not a place where ships survive for long.
another quite effective ( surprisingly) loadout for the Medusa is to load it up entirely with beams, specifically phase beams and tactical beams, it only adds a little bit to a fleet for killing really big ships but it will obliterate nearly all frigates, fighters and it's highly effective against phase ships, just hold the beam on them and their AI will usually tell them to not unphase until they absolutely have to which means they'll pop out, take lots of damage, phase back out, Overload, Die. Slap PD AI on there and it becomes a fearsome protector of your fleet from those pesky missiles.