I prefer to still run in a 4 antimatter cannon loaded Medusa.
This. ludicrously effective.
This is the variant I roll with atm.
Max. capacitors to make the most of the most of hardened shields & the Medusa's inherent excellent shield efficiency.
Capital ship strength shields on a destroyer really are quite insane.
The only thing I'm not convinced of is what to put in the universal mounts.
I've tried IR Pulse and I've tried Light Dual Autocannons, but am unconvinced by either.
I think the answer might be missiles; either Reaper Torps, or Annihilator Rockets.
Hmm, on second thoughts tactical lasers might work really well.