Looking at your builds PrimeMinister, my impression is that most of them are bad. I see insufficient anti-shield, random missiles, not enough finishing power, too much PD, no PD, too many beam weapons, fighter speed mismatch, and
LOTS of range mismatch.
You need high efficiency anti-shield weapons to win the flux war first. Then you need high hit strength weapons to break armor. Finally you need high DPS/burst weapons to take down hull and secure the kill.
Some build examples from my latest game:
Aurora is a player-flagship focused on bursting down most anything. I dump sabots and AMBs to force an overload, fire AMBs to break armor, sweep over with Ion Pulsers for DPS and disabling weapons, then usually finish with AMBs as they end their cooldown. The Swarmers are just on there to fill slots, add DPS, and pressure small ships. I could have skipped PD but I didn't.
Venture is mainly a brick. It has HACs and Graviton for dealing flux pressure, sabot to drive off rushers, and finally Gorgons to deal real damage. I skipped PD because it has Mining Drones for that and it can't move very fast while running from missiles anyways.
This Brawler is mediocre, but it can run up enemies' flux, disable weapons with its Ion Cannon, threaten with its Reaper (until it wastes it), and deal decent hull damage. It might even stay alive due to its decent speed and shields.
Beam Medusa is a waste of a Medusa, but at least it is functional with the weapons I had at the time. It can run down weak ships and eventually wear them down, it can support allies' efforts with its Graviton and Ion Beam, and it can sometimes deal hull damage with its Harpoons. The PD can probably stop Salamanders and keeps it from panicking at the sight of missiles.