I think this is the first time I saw this in the current version.
Mid battle, my XIV Onslaught just stopped firing all autofire weapons. Toggling autofire on and off did nothing. I could still fire the weapons manually without trouble. This meant point defense was worthless.
Eventually, I fixed it by setting the ship to autopilot (to attack an enemy) at which point it started firing without problems, then turning off autopilot and re-engaging autofire for weapons the autopilot had turned off. At that point it worked normally.
I saw this a few times in the last patch too. It seems very rare, and only happens during long battles. The ship just... turns off guns.
I am running pure vanilla, no mods, normal battle sizes.