I'm not sure if anyone else has experience with this or not, but with Nexerelin active, VICs homesystem of Empyrean gets quickly steamrolled by multiple faction invasions almost immediately, with even the smallest of attacks conquering worlds without a fight.
Plegethon in particular seems to be a focus of enemy attention, and boasts virtually no defences against attack, making its capture all but inevitable and crippling the factions ability to field fleets.
I feel like the defences of these critical planets is sorely lacking, and it's an absolute pain to play as them, because without constant player intervention the faction is basically just free real estate to be carved up by everyone else in the sector.