As long as you don't have to pick a certain career path upon starting a new campaign, and then having to stick with it for the rest of the game, I'm fine with it..
However, there should be a logical way to be able to switch careers... If youre an infamous pirate it should be hard to become a soldier for a faction that hates you for raiding them. Though you should'nt have trouble to get enlisted in the army of their enemies.
I know theres going to be a reputation system and I'm thinking of something like Freelancer did, so it would be great if you had job-related skills that aren't linked to any reputation or career path skill or whatever. If I'm a hideous pirate I might wanna start mining to produce my own ships or weapons or whatnot, or I might want to start trading to launder (gain more) money..