I would destroy the sector just to make them stop sending their expeditions at me, and to stop chasing pirates to save their cowardly hides. Of course, that only takes care of majors, not pirates that go after me. Pathers can be avoided completely if I have enough worlds (from Industry skills) to spread out the aggro industries and do not use cores.
The only way to get an empire (at least as big as all of core worlds) is to abuse alpha cores. Without cores, player can only comfortably manage seven or eight worlds with all of the colony skills. Enough for a new faction, but not enough to rule all of core worlds (let alone the whole sector) with an iron fist. Only way to take over core is to destroy their markets then build new ones.
Hegemony is easily bribed, unless the warning is missed or player forgets about them and they steal cores because default option is to comply. The worst part of alpha worlds would be the Pathers cells if their sabotage events were not bugged. Currently, Pathers are bugged so that the worst they do if ignored is permanent -1 stability, because unless stability is 2 or less, sabotage checks always fail.
After playing many versions were I reloaded games due to losing rare ships and items, I like being able to build as much as I want, although that does not happen until close to endgame. What is missing is being able to do more strategic things than simply build-up several colonies to form a new faction or destroy all of core worlds.
What you say about colony building may have been true last release, but with ships and colonies more expensive and slower to build, I need to babysit far longer before I get a strong enough fleet and my planets can repel expeditions. Also, endgame enemies now use multi-capital fleets, with better attack power to crack defenses, and I cannot be certain my colonies can withstand that until they grow big enough and I acquire Planetary Shield. Sure, a set of colonies can become self-sufficient like last release, but it takes much longer to get there. With Growth Incentives massively toned down, growing big colonies take much longer. Finally, some industries have much higher requirements than last release. Low hazard Terran with five resources at -1 would have been enough back then, but not today.
Also, even if my colonies can repel expeditions, they now cost rep if they fail, and I need to farm bounties to rebuild rep. Of course, there is bribing, but expedition alerts are frequent enough (with Free Port on) to consume profits (of about a million credits) from colony income per month once they hit a million per threat, unless I have many colonies through alpha overuse.
As for how I play. My last game was mostly combat and raiding. Did some smuggling and exploration on the side, but the main focus was being a pirate (by mostly targeting other pirates) or space cop. I did more exploration later in the game when I could afford to babysit less.
As for accessibility, yes, there are many ways to boost it. All it takes to crash that is for multiple factions to formally declare war on you and you will see that plummet. So far, all they do is send their war fleets at you (under so-called expeditions) instead of at the pirates and pathers that are wrecking their markets.