I would say I'm in the late-game and from what I've gathered, it seems like PD weapons are the best options in terms of warship loadout. I'm mostly running Triyias and Swaras, with maybe some Reina IIs, and Weiss IIIs for ships with large turrets. S-modded Stabilized Shields and having Hardened Shields, along with the efficiency of PD weapons allow me to close the gap if need be and then just face-tank a win, typically punching above the ship's weight. Even with something like the Maisya(SP), I opted to use all Merupakas, save for 2 Chorus AAMs. And an empty medium turret, which I may rethink later. There are other details as well, like elite Point Defense being a must, but in terms of UAF weapons, I feel like non-PD weapons aren't viable options and could use more balancing?
Maybe I'm just wrong and others can share some of their builds that don't rely mainly on PD weapons?