Symmetry is also redundant as a craft requirement in space. Symmetry is important for flight craft due to the aerodynamic requirements. In space, those requirements do not exist. The important factors are more so targetting profile and weapon coverage.
If you look at the Odyssey, its weapon mounts are portruding from its long frame, and thus in a 3D plane would have excellent coverage as the ships body would not interfere with the firing arcs. Additionally, a long slender ship would need less rotational force to "rotate" the ship along its main axis in a 3D plane, thus allowing it to rotate and position its weaponry much more easily. This is as opposed something like the dominator or onslaught, where frontal heavy weaponry have very limited firing arcs and its wide diameter greatly increases in the force require to "rotate" the ship in a dogfight.
This above sort of design philosphy is one argued strongly for in "the expanse" sci-fi series. The author actually went into great detail with fans explaining why ships would look "more like office buildings".
From my perspective, ship design that "don't make sense" are ships that fire broadsides. In naval warfire it makes sense because the firing "arcs" and positioning is more or less on a 2D plane. In space, the ability for a ship to have portuding weapon mounts and that can fire in a 180 degree arc (the only areas where there is no coverage is the area "below" the weapon mount), makes fire concentration most significant towards the front as well as the rear, as opposed to the sides (since weapons on all "sides" of the ship can concentrate fire towards the front". Additionally, the ability for "spin" and "rotation" makes broadside fire much less important. What becomes more important is the targetting profile of a ship. A ship that fires broadsides have a wide profile relative to its target. A ship with a slender body allows it to have a small profile, while maintaining the same strong fire concentration. Thus the wide body of the dominator, makes a lot less sense compared to the long body of the oddysey.
That said, the oddysey does have one small thing that doesn't make sense. concentrated fire from all of the oddyseys main guns will create a larger profile than what is actually required of the ship. But other than that, its actually a really scientific lay out of a battle cruiser.