I'm fond of this build:
5 PD lasers (the short range 75 dps versions), 2 Graviton beams, and 2 Light Mortars on the universal slots. Then add Augmented Engines so you're fast, Hardened Shields so you're even more difficult to overload, and Advanced Optics gives you a lot more range on the PD lasers and makes the graviton beams very long range.
You don't have the front end damage of antimatter blasters, but with all the 75 DPS PD lasers and 100 DPS graviton beams you can shred enemy fighters - and with your speed and maneuverability combined with the intense PD laser coverage you won't have anything to worry about from missiles. For most larger ships you can move into range of your PD lasers (which is 525 thanks to advanced optics) and down their shields with that, then a bit closer and your mortars can start pelting them for a bit of extra oomph vs their armor.
All your guns are extremely energy efficient, as is your shield, so you can wear down just about anything given a little time. It's the perfect build against carrier groups, as you can take their entire bomber and fighter force at once and then move in for the kill on the carriers after disposing of their escort.