I've found an Enforcer armed with close-range weaponry and SO installed with maximum vents rips everything that exists to shreds, even Cruisers.
x2 Flak Cannons (in the usual positions)
x2 Heavy Autocannons (I'd use Heavy MGs, but I don't have any in the bit of space I'm currently in)
x1 Assault Chaingun
x4 Salamander MRM (Single)
About a quarter of the remaining OP should go to Capacitors - I've discovered in my trials that the AI cannot withstand having a low Flux limit - they flounder and can't move out of the way in time, especially when it comes to strike weapons like multiple wings of Daggers. The rest go to Vents (preferably all 20 if you have the OP to spare).
I've got my current loadout as Especially if you've got America Roth (I love that name for some reason - he also shares the same portrait as my main character, so I have made him my second in command) as a level 16 Officer armed to the teeth with Level 10 Combat, Level 10 Target Analysis, level 7 in Flux Modulation (good for this Enforcer SO loadout) , and a bunch of other level 1 and 4 skills - this thing becomes unbeatable. The Enforcer can catch up to whatever it likes, blow it to pieces, and move on. The never-ending pain train of America Roth is awesome to watch and a thing to marvel.
With my character skills, he's actually got a 16 Capacitor and 20 Vent loadout - he can absorb all the damage he wants and dish out more.