An interesting problem that affects most sandbox games.
In real life, when people become so wealthy that they've bought everything they need or want, and already invested enough to ensure luxury for even their great-great-grandchildren, they usually start either political careers to achieve power as well as wealth, or some kind of meaningful work to make the world a better (or worse) place according to their values.
For example George Soros tries to build democracy in unfree countries through education and research, in effect trying to 'destabilizing' dictatorships and replace them with something better.
In Starsector it would be interesting if reducing a market to zero stability long enough made it change factions. This would have to require massive amounts of trade goods or large scale disruption of fleets.
A couple things might make this easier:
-The ability to own your own factory for a particular trade good, even if it was just on an existing planet/station rather than a new one.
-The ability to charter multiple large fleets without leading them yourself, and direct them to ply certain goods along certain routes.
Since a lot of the planets only have hundreds or thousands of people on them, right now it's easy to destabilize them. The scale would have to be vaster to be interesting for end-game millionaires.
For example, if you were a humanitarian, you could send thousands of tonnes of food, supplies, and equipment to war-zones to stabilize them.
If you feel like a jerk, you could start a drug factory and flood a market with drugs until it destabilized into war, then flood it with guns from your gun factory.
Or you could just maintain the balance of power in the universe, by destabilizing planets when necessary, and then nudging another faction into power there to keep any one faction from ruling the whole galaxy.
But Starsector is a game about flying spaceships around. Games are usually better when they have a limited scope. The kind of things above make it become like a simulation of the entire galaxy, which might be boring since you just played the game in the first place to fight with spaceships, and now you become mired in nation-building, foreign aid, and diplomacy.
So maybe there comes a time when you've played the game so much that you have to take a break for a while.