Some settings are ripe for changing and others cause issues. Here is my small personal settings mod:
{
"enableUIStaticNoise":false,
"enableShipExplosionWhiteout":false,
"minCombatZoom":1.0,
"maxCombatZoom":2.0,
"playerMaxLevel":99,
"minPirateBases":0,
"maxPirateBases":2,
"minLPBases":0,
"maxLPBases":2,
"processMessagesWhileSavingOrLoading":false,
}
That last setting in particular helps with mouse clicks causing game crashes while the game is busy saving.
The # of bases arguably makes the game a little easier; at least the pirate raid part of it. Since LP sabotage currently is bugged, LP bases are not as much a priority target.
I would also recommend you play the vanilla game for a while and get deep into it. There's a lot of stuff to do there, mods are really just for weapon and ship variety.
When you do add mods, I recommend sticking to a curated minimum like: Blackrock Driveyards, Dassault-Mikoyan, Diable Avionics, Interstellar Imperium, Shadowyards, Ship & Weapon Pack, Starship Legends, Tiandong Heavy Industries, Underworld. As well as any utility mods you might want.