Gryphon is a warship that is at least as flimsy as a carrier or civilian, yet, the AI treats it like a warship on par with Falcon or Eagle. That is a disaster waiting to happen. If I want to play with a missile-boat, I rather use a different ship.
After much experimentation, my preferred use for a gryphon is... not to use a gryphon. >.<
If I really don't have anything better, I'd go for the hammer launcher + sabot pods, with a flak cannon and a mix of light assault guns (anti-fighter) and vulcans (pd coverage where the flak cannon is out of arc). Forward small missiles vary based on what you're doing with it; torpedos if it's a specialized anti-starbase build, harpoons or annihilator rockets for general purpose.
The hammer launcher, in particular, is noteworthy among large missile weapons for having a high DPS - its ammunition reserves are poor, but it can put out damage much faster than the alternatives.
I have used Gryphon once or twice when it was my first recovered upgrade over the trio of Enforcer, Mule, and Shrike (P). Likewise, I gave it Hammer Barrage (because I can buy it at Open Market) and otherwise treated it as an extra large Enforcer (D). Spam rockets, tank, and die.
Hammer Barrage is also noteworthy of being the only Open Market large missile. (Not a big deal now that Locusts are common in Black Market or some pirate loot.) This is why I make a big deal for good ships that can use Hammer Barrage. So far, the only ship that qualifies is Legion (XIV), which cannot be bought or produced. Old pre-0.7.2 Aurora with large missile mount would have been a great ship for dumb-fire large missiles.
It's a shame though, the Gryphon looks great and it has an interesting weapon layout. I love the look of the Gryphon. Perhaps it can be reworked with lots of composite or synergy mounts to be like an Aurora. Or perhaps a MK II version which is changes most weapons to non-missile weapons and a larger flux dissipation.
I like to see Gryphon evolve into something similar to pre-0.7.2 Aurora. Back in those days, Aurora was a superior Gryphon with High Energy Focus instead of Missile Autoforge, and Aurora could fight back with two Heavy Blasters (and possible IPDAI IR Pulse Lasers) while Cyclone Reapers were on cooldown.