1) Don't use any 'Speeder Uppers' that try to free memory. These are rubbishware and you don't need them. Get a handle on your running processes instead and terminate hungry ones that you don't need. Some of these are present as a Service and can have their startup modified.
Windows 7 and newer already minifies memory for processes that are not actively needed when another one such as a game comes along and wants it.
2) DON'T do the same with native Windows Services. This will only cause you grief and the memory gain is unnoticeable. The exception being Defender and Indexing Services (Windows Search) if you don't need them.
Having a page file helps. If you have a spare USB drive, using it for ReadyBoost helps even more. Sorry to do this, blaa.