Use Safety Override for...
* Pure trade fleets - you do not need weapons, stack Unstable Injector and Safety Override on all of your so-called combat frigates and run from everything.
* Lashers - you are stuck with machine guns and LAGs, dissipation is not good enough, and Luddic Path are a threat. Use Safety Override to even the playing field at worst.
* Pursuit frigates - it is a must to catch-up to faster targets if you want them dead.
* Anything with HMGs, chainguns, or other short-ranged weapons - if you have poor shot range, might as well stack more speed; great for Enforcers and Eagles.
Safety Override is useful on cruisers for endgame battles, if you cannot configure them for sniping. Eagle with HMGs/Chaingun, Ion Cannons, and Burst PD, will rip through smaller enemies.